Synthesis And Characterization Of Some Metal Complexes Of ZnII With 110- Phenanthroline And Some Amino Acids Anti-Inflammatory And Analgesic Activities Of Its Complexes.

Abstract New mixed ligand complexes of ZnII with 110- Phenanthroline and some amino acids were prepared in the solid form and characterized by elemental analysis conductivity magnetic moment measurement FT-IR 1H-NMR 13C-NMR and FAB mass studies. To examine anti-inflammatory and analgesic activities of its complexes some Swiss albino mice of 05-07 weeks old were taken. One dose of the test compounds of 10 mgkg was selected throughout the research work. The anti-inflammatory activity of the test compounds were determined by carragenan induced mice paw edema inhibition method and however the analgesic activity was determined by acetic acid induced writhing methods. These four compounds showed positive effects as anti-inflammatory and analgesic agents. Anti-inflammatory and analgesic activities of the test compounds at 50 mgkg were quite comparable to those of standard drugs at 10 mgkg.