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Evaluation of Antihyperglycemic and Hypolipidemic Action of Euphorbia Caducifolia Latex Powder on Alloxan- Induced Diabetic Rats

Journal: International Research Journal of Pharmacy and Medical Sciences (IRJPMS) (Vol.1, No. 5)

Publication Date:

Authors : ;

Page : 26-31

Keywords : Alloxan; Antihyperglycemic; Diabetes Mellitus; Hypolipidemic.;

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Abstract

Background: The study of Plants having antihyperglycaemic and hypolipidaemic activities may give new approach in the treatment of diabetes with lesser side effects. Objective: The study was intended to evaluate the antihyperglycemic and hypolipidemic action of Euphorbia caducifolia latex powder in alloxan-induced Diabetic Rats. Materials and Methods: Diabetes was induced in albino rats by using alloxan monohydrate (150 mg/kg). Rats were divided into five groups of six animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with Nopal. Group 4 and 5 received 100 and 200 mg/kg body weight of ECLP. Blood samples were analyzed for blood glucose on day 1, 7, 14 and lipid profile on day 21. Results: The ECLP showed significant reduction (P<0.01) in blood glucose level and serum lipid profile levels with 200 mg/kg body weight in alloxan-induced diabetic rats as compared with the control. Conclusion: It is concluded that ECLP is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats.

Last modified: 2018-09-14 23:07:18