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CHARACTERISTICS OF FIRE AND EXPLOSIVE PROPERTIES OF ANTIVIRAL DRUG TRIAZID AND ITS MAIN SEMIPRODUCTS

Journal: Pozharovzryvobezopastnost/Fire and Explosion Safety (Vol.25, No. 3)

Publication Date:

Authors : ;

Page : 15-20

Keywords : ;

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Abstract

Now the new anti-virus substance "Triazid" (5-methyl-6-nitro-7-oxo-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidinide L-argininium monohydrate) passes the state registration procedure as a medicament for the subsequent organization of its production and applications in the Russian Federation. Therefore there is a need in identifying of fire and explosive hazard characteristics of "Triazid" (I) and two semiproducts of its synthesis (5-methyl-1,2,4-triazolo[1,5-a]pirimidin-7-one (II), 5-methyl-6-nitro-1,2,4- triazolo[1,5-a]pirimidin-7-one (III)). These indices of compounds (I)-(III) are determined by experimental and computational methods. At the experimental finding of the auto-ignition temperature of (I)-(III) and the fire temperature of (I) and (III) according to GOST 12.1.044 we meet the next technical difficulties: • upper limit of the working range of apparatus OTP does not allow to determine the auto-ignition temperature of the compounds • intensive decomposition of compounds (I) and (III) extinguishes aburner flame of apparatus OTP It does impossible definition of their fire points Express tests on auto-ignition (contact of the samples with a red-hot spiral) gave positive results for the compounds therefore we replaced the standard apparatus OGNM on device TEP, The resultofthe workis determinationoffire andexplosive hazardcharacteristics ofthe newdrug "Triazid" (I) and two semiproducts ofits synthesis.

Last modified: 2018-10-18 17:21:43