Allele Frequency Of P53 Gene Arg72Pro In Sudanese Meningioma Patients And Controls

Abstract The Meningiomas are one of the commonest intracranial tumors and account for 20 of all primary intracranial neoplasms. However the true incidence is likely to be much higher since many benign meningiomas do not produce symptoms. In autopsy studies 2.3 of individuals harbored undiagnosed asymptomatic meningiomas suggesting that such tumors are up to 1000 times more common than their clinically detected counterparts. Material and Method This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. Result Molecular screening of the 180 meningioma specimens showed that the most common allele of p53 gene codon 72 in meningioma was the arginine variant Argarg in 157 87.2 of the cases.