Synthesis And Identification 1-3 Diazepine From Ibuprofen

ABSTRACT The research was involved preparation of 1-3 diazepin from 2-4-isobutylphenyl propanoic acid ibuprofen by many steps includingSchiff bases1-3 Oxazepine and 1-3deazepine ibuprofen was used a basic substance to prepare of these compounds via many steps the first Step including prepared ester from Ibuprofen in absolute Ethanol solvent in the presence H2SO4 con so the following derivative was produced M1. Step two including prepared hydrazid derivatives from reaction the ester with NH2-NH2 H2O.80 in the absolute Ethanol solvent were producedM2. In the next step a new Schiff bases compound prepared by a condensed reaction ofM2 with Acetophenone and 4-chloro Acetophenone was produced K1K2. The third step includes preparation of two Oxazepine ring by a reaction of tow Schiff bases produced by the first with maleic anhydride in dry benzene solvent to give the compoundH1 H2. In the end step includes the preparation of two deazepine ring by reaction 1-3 oxazepine ring with phenyl hydrazine to product the compound12.These synthesized compound have been characterized by melting point Elemental analysis FTIR and HMNR spectroscopy by their UN corrected melting points elemental analysis and FT-IR spectra