The Effects Of Antiretroviral Drugs On The Absorbance Characteristics Of Blood Components
Journal: International Journal of Scientific & Technology Research (Vol.4, No. 9)Publication Date: 2015-09-15
Authors : O. I. Ani; S. N. Omenyi; C. H. Achebe;
Page : 154-160
Keywords : Index Terms Absorbance; Antiretroviral drug; coating effectiveness; HAART; Human immunodeficiency virus; Lymphocyte; plasma;
Abstract
Abstract The effects of antiretroviral drugs on the absorbance characteristics of blood components have been studied. The methodology involved the serial dilution of the five different antiretroviral drugs two HAARTFDC and three single drugs and the subsequent incubation with the blood samples collected from ten blood samples of HIV negative persons for the absorbance measurement using a digital Ultraviolet Visible MetaSpecAE1405031Pro Spectrophotometer. Reflectance Dielectric constant etc were derived from the absorbance data. For these drugs to be effective as HIV blockers they should be able to coat the surfaces of the lymphocytes. The question therefore arises as to what extent these drugs are able to coat the surfaces of the blood cells This was established using the extent of absorbance change. Models for coating effectiveness were formulated. The coating effectiveness was therefore calculated from peak absorbance values. Red blood cells were shown not to give reliable results. The results obtained however establish the fact that some coating of the drug had really occurred on the surfaces of the lymphocytes. The drug films were determined for lymphocytes and used to explain some observed clinical findings. The use of the findings of this work in drug design may be expected to yield good results.
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Last modified: 2015-11-13 18:32:49