Polymorphic Exanthem Induced By Amoxycillin In A Child Case With Infectious Mononucleosis

Seven year old girl presented with sore throat, fever, fatigue; amoxicillin clavulanic acid therapy had been started in a clinic. In 7th day of treatment widespread rash all over her body began. On dermatological examination all over the body was covered by target-like, petechial lesions and in some areas maculopapular lesions with becoming faded by pressure. In laboratory examinations 3-5 times increased liver enzymes, complete blood count with lymphocytosis were found. In serological tests EBV Viral Capsid Antigen (VCA) IgG and IgM were positive. EBV IgM/EBV IgG ratio was found 3 times higher. Based on clinical, histopathological and laboratory examinations it was thought as Epstein Barr Virus (EBV) rash induced by amoxicillin. Infectious mononucleosis caused by EBV infection, usually affects children and adolescents. Aminopenicillins used during this infection may cause maculopapular rash. Development of polimorfic lesions is relatively rare. Although rashes seen while the treatment with aminopenicillin, drug eruptions must be thought firstly;infectious mononucleosis must take place in differential diagnosis.