CURATIVE EFFECT OF FORMONOETIN-7-O-Β-D-GLUCOPYRANOSIDE FROM METHANOLIC EXTRACT OF OPERCULINA TURPETHUM IN FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS

Objective: To investigate the anti arthritic potential of isolated compound Formonoetin-7-O-β-D-glucopyranoside from Methanolic Extract of Operculina turpethum. Methods: F-7-β-D-g was subjected to assess the anti arthritic activity by foot pat thickness, body weight measurement, rheumatoid factor, spleen index score assessment and hematological estimation using a model Complete Freund's Adjuvant (CFA) induced arthritis in wistar rat. Result: Administration of F-7-β-D-g at the doses of 10, 20, 40, 50 mg/kg b. w. p. o exhibited statistically significant (p < 0.001) inhibition of the edema, rheumatoid and spleen index factors significantly increased (P < 0.001) the Heamoglobin (Hb) level, Red Blood Cells (RBCs), White Blood Cells (WBCs) count, Erythrocyte sedimentation Rate (ESR) compared to arthritic treated groups. Conclusion: F-7-β-D-g from the methanol extract of Operculina turpethum holds anti arthritic property by modulating bone erosion. Keywords: Operculina turpethum, Formonoetin-7-O-β-D-glucopyranoside, Rheumatoid arthritis, Freund's complete adjuvant-induced arthritis.