Relationship between Therapy with A1-Adrenoceptor Antagonists (A1-Blockers) for Benign Prostatic Obstruction and Sexual Function

Lower urinary tract symptoms (LUTS) are common in elderly males and have multifactorial aetiology. The impact of LUTS on individual's health and quality of life often motivates patients to search for treatment. The administration of α1-adrenoceptor antagonists (α1-blockers) is considered as a first-line choice for drug treatment, because of its well documented effectiveness and safety. Still side effects are relatively common, but rarely result in discontinuation of therapy. There is a steadily growing interest for the impact of these therapeutical agents on male sexual function. Our aim is to present adequately, through the review of the international relative literature, the effects of currently and mostly used α1-blockers on sexual function of patients suffering from LUTS due to benign prostatic obstruction.