Two Cases of Pure Hair Nail Ectodermal Dysplasia in Two Yemeni Siblings

Ectodermal dysplasias (ED) are a rare group of genodermatoses affecting tissues of ectodermal origin namely: hair, nails, teeth, and sweat glands. Pure hair, nail ectodermal dysplasias (PHNED) are very rare, and involve only hair and nails, while other ectodermal structures are intact. To date only 20 cases have been reported inthe world literature. We report two cases of PHNED in a 15 years old Yemeni boy, and his 2 months old sister, who were born with total absence of hairs and dystrophic 20 nails. All other family members were not affected.