Possible Case Report of Furosemide-Induced Psoriasis

Purpose: After reviewing PubMed, drug-induced psoriasis has been previously reported. This case is believed to be the first furosemide-induced psoriasis reported and includes a summarization of antihypertensive-induced psoriasis on some of the previously published literature. Summary: A 32-year-old African American female with hypertension secondary to edema was noted to have developed psoriasis 3.3 years after the initiation of furosemide 20 mg orally once daily. She initially had a new-onset rash to hydrochlorothiazide 25 mg orally once daily after 1 week prior to switching to furosemide. After presenting with her psoriatic-like skin lesions all throughout her body while on furosemide for 3.3 years, dermatologic biopsy confirmed the psoriasis diagnosis. After discontinuation of furosemide and initiation of topical and oral supportive medications, the patient's psoriasis resolved after 4 weeks. She was changed to lisinopril 10 mg orally once daily then finally switched to losartan 50 mg orally once daily with spironolactone 50 mg orally twice daily. Conclusion: Using the scale of Naranjo et al. it was determined that furosemide use was the possible cause of the patient's psoriasis. This report can contribute to the literature by describing another druginduced psoriasis and provide a possible first case report of furosemideinduced psoriasis.