Effects of Heparin Therapy on Hexagonal Lipid Neutralization Test

In this retrospective study; we evaluate the effects of heparin therapy on hexagonal lipid neutralization test. We identified 8000 patients in our hospital system that had been evaluated for lupus anticoagulants. Among these patients we found 100 patients who had been evaluated for lupus anticoagulants while they were on and off unfractionated (UFH) heparin. 23% had positive result of hexagonal lipid neutralization test before receiving heparin while 59% had positiveresult of hexagonal lipid neutralization test after receiving heparin. We conclude that there is an association between heparin therapy and positive result of hexagonal lipid neutralization test.