CORRELATION OF SERIC BIOMARKERS AND CELLULAR ELEMENTS IN SPUTUM AND BLOOD, IN RELATION TO THE GRAVITY OF COPD

Research in relation to the biomarkers to define exacerbation, gravity and it's progress in COPD has been made and continued to be made. By present literature, it result that biomarkers correlate with clinical gravity, with the time of the recovery period, persistence of symptoms and clinical resolution, with exacerbation frequency. Aim: The study has as an aim, the evaluation of the correlation of seric biomarkers and cellular elements in sputum, and blood in relation to the gravity of COPD. Method: The abstract is an observing prospective study conducted on the Regional Hospital “Fier”. In the study, patients presented with exacerbated COPD of stages III and IV were considered. Based on a protocol, in patients with COPD exacerbations, anamnestic data as well as data from clinical and laboratoric examinations was collected. It has been defined in the time of introduction for the reason of COPD exacerbations and after 21 days, CRP, IL6, PARC/CCL18, cellular content of sputum and blood. The statistical analysis was conducted through SPSS (Statistical Package for Social Sciences) 20.0 and Medstat. Values of p ?0.05 were considered significant. Results: In the patient with COPD exacerbations of stages III and IV, significant changes of cellular elements in blood and sputum were observed. In relation to the values of the original CRP in normal boundaries there is no case in the D4 category and value higher than the level from 40 to 200 mg/l are in relation to categories D3 and D4. In the examination of IL6 in exacerbation, it can be observed that cases with a level >7 pg/ml are grouped in categories D3 and D4; PARC in values >30ng/ml are 91.1% of cases, whereas in values >60 ng/ml are in 66.1% of cases. The greatest number of cases PARC in the values >30ng/ml, as well as for values >ng/ml, are in categories D3 and D4. According to the data of the correlations analysis, it results that original CRP correlated in a significant manner with COPD stage (p=0.005); IL6 (p=0.038). PARC (p=0.054). Conclusions: It results that there are significant changes in stages III and IV in relation to the stage of inflammation based on cellular structure in sputum, number and cellular elements of blood and the levels of CRP, IL6 and PARC/CCL18 in blood.