PROGNOSTIC MODEL TO DETECT COMPLICATIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.24, No. 24)Publication Date: 2012-12-30
Authors : M. P. Kopytsya; N. V. Tytarenko; N. V. Bila; O. L. Oparin;
Page : 23-31
Keywords : N-terminal proB-type natriuretic peptide; acute coronary syndrome; prognosis;
- PROGNOSTIC MODEL TO DETECT COMPLICATIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME
- PROGNOSTIC VALUE OF BLOOD GLUCOSE LEVELS IN DIABETIC PATIENTS UPON ADMISSION AND ITS OUTCOMES IN PATIENTS WITH ACUTE CORONARY SYNDROME
- PROGNOSTIC IMPLICATION OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN ACUTE CORONARY SYNDROME PATIENTS
- CLINICAL AND PROGNOSTIC ASPECTS OF THE ASSESSMENT OF BRAIN NATRIURETIC PEPTIDE AND GRACE IN PATIENTS WITH ACUTE CORONARY SYNDROME
- A STUDY OF PREVALENCE OF CHRONIC KIDNEY DISEASE IN ACUTE CORONARY SYNDROME AND ITS IMPACT ON THE MANAGEMENT AND OUTCOME IN ACUTE CORONARY SYNDROME PATIENTS
Abstract
The aim of this study was to define the utility of the measurement N-terminal pro-brain natriuretic peptide (NTproBNP) and other clinical and biochemical markers to predict adverse events (death, stroke, unstable angina, re-infarction, or necessity of revascularization at 1 year in patients with acute coronary syndrome
(ACS). Parameters with significant differences in patients with and without complications were taken for ana-ly¬sis: age, heart rate (HR) at admission, levels of hemoglobin and NTproBNP. Curves of sensitivity and spe¬ci-fi¬city were used based on the method of ROC analysis and cut-off values were chosen for each variable. Ball scoring was performed for each parameter regard to the cut-off value and a scale for calculating the summarized diagnostic coefficient (DC) by the method of Gubler was offered. A multimarker approach includ¬ed on NTproBNP, hemoglobin, HR at admission and age and the summation of balls based on offered sca¬le and calculating DC provides in¬formation in terms of ACS prognosis at 1 year, with a worse outcome for those with diagnostic coefficient has negative value (sensitivity 87,5 % and specificity 75,6 %).
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