LONG-TERM STABILITY STUDY OF COMPLEX DARUNAVIR:Β-CYCLODEXTRIN
Journal: Journal of Pharmacy & Pharmaceutics (Vol.3, No. 1)Publication Date: 2016-02-18
Authors : Ana Carolina Kogawa;
Page : 1-5
Keywords : Î?-cyclodextrin; Darunavir; Degradation products; LC-MS; Long-term stability;
Abstract
Darunavir, a protease inhibitor most widely used in the treatment of HIV infection, was complexed with β-cyclodextrin due to the low solubility in water and its poor bioavailability. This research describes the study the long-term stability of the complex darunavir: β-cyclodextrin which was kept in a climatic chamber for 24 months at 30°C ± 2°C and 75 % UR ± 5 %. The samples were analyzed using LC-MS, 250 mm × 4.6 mm CN Luna column, water + 0.1 % glacial acetic acid: acetonitrile + 0.1 % glacial acetic acid 60:40 (v/v) as mobile phase, flow rate of 1.0 mL min-1, UV detection at 268 nm and ambient room temperature (25°C) before the start of study and thereafter 3, 6, 9, 12, 18 and 24 months. The data obtained associated with the infrared, TG, DSC and X-ray diffraction analysis was sufficient to study the behavior of complex darunavir: β-cyclodextrin. The results of this research indicate that the stability of the complex darunavir: β-cyclodextrin is high under conditions associated of temperature and humidity.
Other Latest Articles
- ANTIDIABETIC, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF THE FUNCTIONAL MOLECULES ISOLATED FROM THE SEED AND PEEL OF JACKFRUIT (ARTOCARPUS HETEROPHYLLUS)
- Antidiabetic, Antioxidant and Antibacterial Activities of the Functional Molecules Isolated from the Seed and Peel of Jackfruit (Artocarpus heterophyllus)
- ANTIDIABETIC, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF THE FUNCTIONAL MOLECULES ISOLATED FROM THE SEED AND PEEL OF JACKFRUIT (ARTOCARPUS HETEROPHYLLUS)
- EFFICIENCY OF ATMOSPHERIC PRESSURE NITROGEN GAS REMOTE PLASMA STERILIZATION AND THE CLARIFICATION OF STERILIZATION MAJOR FACTORS
- EVALUATION OF ANTIBIOTIC PRESCRIPTION FOR UPPER RESPIRATORY TRACT INFECTIONS IN THE COMMUNITY PHARMACY SETTING
Last modified: 2017-01-06 21:25:40