STATE OF PRO- AND ANTIINFLAMMATORY IMMUNITY LINK IN PATIENTS WITH COMBINING COURSE OF CHRONIC OBSTRUCTIVE LUNG DISEASE AND CHRONIC PANCREATITIS

In 67 patients with chronic obstructive bronchitis (COB), which in 46 cases, proceeded in combination with chronic pancreatitis (CP), studied the state of pro-and anti-inflammatory immunity link and levels of antibodies to the liver and lungs tissue. It was shown that COB exacerbation leads to increased levels of IL-1 and TNF-α against the oppression of IL-4 production and inadequate response of IL-6. In case of combining course of COB and CP changes in cytokine state were reliable. Increasing of IL-6 level indicate a significant ac¬tivation of nonspecific humoral immunity. At the same time shows an increase of antibodies to the lungs and liver tissues number, which was more pronounced in case of diseases combination, which is regarded as the possibility of disease progression and complications.