VASOMOTOR ENDOTHELIAL FUNCTION IN HYPERTENSIVE PATIENTS WITH RENAL ORIGIN

The aim the study was to investigate endothelium dependent mechanisms that characterize the significance of endothelial dysfunction in hypertensive patients depending on its severity in patients with chronic kidney disease (CKD). A total of 73 patients with CKD: chronic glomerulonephritis 34, chronic pyelonephritis 22 and diabetic cardiomyopathy at the age of 22 (54,2 ± 6,2) years, men 52 and women 21. Endothelium depen¬dent (EDVD) and endothelium independent (ENZVD) vasodilatation investigated by the method of D. Celer¬majier et al. (1992). Compared with healthy individuals in patients with hypertension has been a significant reduction in both EDVD and ENZVD, and the emergence of a 2/3 of the low vasodilatation and constrictor re¬sponses to compression and nitroglycerin.