THE INFLUENCE OF CHLOROPHYLLIPTUM ON IMMUNOPATHOGENETIC INFLAMMATION FACTORS IN PURULENT RHINOSINUSITIS PATIENTS SUFFERING FROM INSULAR DIABETES MELLITUS

The efficiency of administration of chlorophylliptum as an immunomodulator as well as that of applica-tion of essentiale and potassium orotatum for compensation of the pathogenetic immunity link malfunctions in purulent rhinosinusitis patients suffering from insular diabetes has been investigated in our work. Under the influence of introduced therapy considerable reduction of superoxide radical exoproduction by cells, red-uction of proinflammatory cytokine content in blood serum (interleucin-1β, interleucin-6, tumor necrosis fac-tor-α) and dynamic reduction of tissue-aggressive factor content in blood serum (average and small molecular circulating immune complexes, autoantibodies to collagen and elastin) have been observed.