THE EFFECTS OF NON SURGICAL PERIODONTAL THERAPY ON TOTAL ANTIOXIDANT STATUS, TOTAL OXIDATIVE STATUS AND IL-6 LEVELS IN GINGIVAL CREVICULAR FLUID AND SERUM OF HYPERLIPIDEMIC SMOKERS

The aim of this study is to investigate the effect of periodontal therapy on clinical parameters, IL-6, TAS (Total Antioxidant Status), TOS (Total Oxidative Status) in serum, GCF and serum lipid parameters and to evaluate the effect of smoking on the interaction between periodontal disease and hyperlipidemia. Materials and Methods: This study included 28 patient, aged between 42-64 years (mean 52.5 ± 10 years), with non-systemic disease and without hyperlipidemia. Patients were divided into two groups: smoking (n = 14) and non-smoking (n = 14). Clinical parameters were recorded at baseline. GCF and blood samples were obtained from patients for IL-6, TAS, TOS and serum lipid parameters. Following baseline measurements and sampling, non-surgical periodontal treatment was performed on all participants. Serum sampling, clinical measurements, and GCF were repeated at the 3rd month. GCF and serum IL-6, TAS and TOS levels were determined by the ELISA method and analyzed using the t-test and univariate variance analysis. Results: There were statistically significant differences between S(+) and S(-) groups at the 1st and 3rd months (p < 0.05). GCF and serum IL-6 and TOS levels decreased while the TAS level increased after therapy in the S(+) and S(-) groups. TC and LDL levels were decreased significantly but HDL level was not increased significantly between groups. Conclusion: There were no significant differences between S(+) and S(-) groups after non-surgical periodontal treatment of serum lipid parameters. Smoking had limited effects on changes of TAS and TOS values after the periodontal treatment of individuals with hyperlipidemia.