INTERCLUSTER-A TOOL TO CLUSTER PROTEIN-PROTEIN INTERACTIONS: DATAMINING OF PROTEIN INTERACTIONS IN PRIMARY OPEN ANGLE GLAUCOMA

A growing number of diseases seem to be associated with protein aggregation and each disease has several proteins involved in it. To obtain a better understanding of the diseases, the proteins involved in it and their primary interaction partners were collected and clustered. A tool is developed to aid in clustering these proteins and all their primary interactors. The tools is used to cluster proteins involved in Primary Open Angle Glaucoma and their primary interactors. A cluster was selected for analysis based on the availability of experimental analysis in literature. The localization of the protein in the chosen cluster was collected. On analyzing four of the proteins in the cluster was found to be heparin binding. Primary open angle glaucoma is known to be associated with loss of retinal vasculature. The tool has helped in finding a cluster of proteins interaction with more experimental data. Also it has helped in finding out the 4 protein associated with the disease that involved in heparin binding among 10500 proteins. This would not have been possible to do manually. Further studying the role of these four proteins based on heparin binding and loss of vasculature in primary open angle glaucoma would give a better understanding of the disease and the molecular mechanism involved in it.