B-CELL LYMPHOMA, UNCLASSIFIABLE, WITH FEATURES INTERMEDIATE BETWEEN DIFFUSE LARGE B-CELL LYMPHOMA AND CLASSICAL HODGKIN LYMPHOMA: A REVIEW OF REPORTED CASES

Grey Zone Lymphoma (GZL), with features intermediate between classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL), is a new entity with limited reported data. A MEDLINE search through July 2013 identified 39 cases of GZL and two additional cases were added from our institution. Comparison of complete remission (CR) rates between ABVD and CHOP-based regimens was performed using Fisher's exact test. The median age of presentation was 33.5 years with a male predominance (59%), mediastinal involvement (89%), and early stage disease (75%). Patients treated with CHOP-based regimens achieved higher CR rates compared to initial ABVD-based regimens (80% vs. 0%;p=0.01). The 2-yr OS was 87% with a median OS that was not reached. Our reviewindicates this lymphoma subtype to have a high incidence of early stage presentation, mediastinal involvement, B symptoms and overall better outcomes with CHOP-based regimens. Additional studies are warranted to further study this disease.