PROTECTIVE EFFECT OF LYCIUMBARBARUM EXTRACT AS ANTIOXIDANT AGENT ON RORIDIN A INDUCED HEPATOTOXICITY IN MALE RAT

The fruit goji berry of lyciumbarbarym, a traditional Chinese herbal medicine, has been widely used in healthy diets due to its potential role in the prevention of chronic diseases. We studied the effects of roridin A toxin in male rat liver and their amelioration by goji extract. Thirty male adult albino rats were divided into three groups (10 rats each). Control group was given only the solvent (DMSO) of roridin A. Group 2 was administered a single dose (0.6 mg/kg) of rordin A mycotoxin (dissolved in 1% DMSO) and left for one week. Group 3 was treated with goji extract (5 mg/kg) using gastric tube for 6 days daily before administered roridin A and left for one week. Roridin A showed high significant increase in the level of cholesterol, triglycerides, total antioxidant in serum and significant increase in glucose and tumor necrosis factor (TNF). There was very high significant decrease in ferritin level in the serum. On the other hand, administration of goji along with rordin A showed a reduction in the above mentioned factors and elevates the ferritin level. Histopathological changes of rat liver coincided with biochemical changes. In conclusion; the treatment of rats with goji extract ameliorated the adverse effects of rordin A. Thus, goji may be used as antioxidant for some toxins.