BIOCHEMICAL AND HISTOLOGICAL STUDIES OF GOJI EXTRACT ROLE ON PATULIN MYCOTOXIN ON MALE RAT KIDNEY

Patulin caused severe damage in several organ systems like kidney, intestinal tissue and immune system. The objective of this study is to show the effects of patulin mycotoxin on some biochemical parameters and histological changes on male rats' kidney. 50 adult albino male rats were divided randomly into 5 groups. Control group was injected subcutaneously daily with distilled water; groups I and II were injected subcutaneously daily with Patulin (0.2 mg/kg/day) for one and two weeks respectively. Group III was treated with the same dose of patulin for two weeks after that they were injected subcutaneously with Goji extract (2ml/ kg /day) for two weeks. Group IV was treated by Goji for two weeks after that they were treated with the same dose of patulin for two weeks. Level of total antioxidant stress (TAS), Blood urea nitrogen (BUN) and pyruvate kinase (M2-PK) were decreased significantly in serum of both treated groups compared with control group, but level of serum creatinine (SCr), Alpha feto protein (AFP) and carcinoembryonic antigen (CEA) were increased significantly in serum of both treated groups compared with control group. Histopathological changes of rat kidney coincided with biochemical changes. In conclusion, consumption of patulin induced renal toxicity. Goji extract may be used as a new therapeutic for patulin toxicity.