AN ASSOCIATION OF FRAGILE X ASSOCIATED TREMOR/ATAXIA SYNDROME (FXTAS) WITH THREE COMMON NEUROLOGICAL PROBLEMS: A REVIEW

Aim: To study the association of Fragile X associated tremor/ataxia syndrome (FXTAS) with Alzheimer's disease and Lewy Body Dementia. Method: A systematic search was performed in various data bases and journals of Neurology. In total over 600 articles were reviewed and out of those, 39 were selected based on selection criteria. Results: FXTAS is associated with Alzheimer's disease and Lewy Body dementia because so many symptomatic and pathophysiological similarities are found between FXTAS and these two neurodegenerative diseases. Conclusion: The association of FXTAS with neurodegenerative illnesses like Alzheimer's disease and Lewy Body dementia is present because of many similarities between them. However, some dissimilarity does exist and some questions remain in addressing the pathophysiology of this association. Therefore we recommend more research in the near future to understand this association to develop and utilize wide-reaching therapies.