EXTRAMEDULLARY RELAPSE OF MULTIPLE MYELOMA

Multiple myeloma(MM) is characterized by malignant proliferation of clonal plasma cellsthat usually produce a unique immunoglobulin molecule(1). Extramedullary myeloma(EM) is a type ofMM defined by the presence of extraskeletal (ie. Soft tissue or visceral) plasma cell infiltrates. EM canbe present either initially at the time of diagnosis (ie. Primary) or at the time of relapse (ie.Secondary)(2). However both are associated with extremely poor prognosis (3). Here we describe a56 year old gentleman who underwent an autologous transplant for light chain myeloma (Lambdalight chain) in VGPR and who presented six months later with abdominal pain, anorexia and weightloss and was found to have extramedullary relapse of myeloma involving liver, spleen and lungs.