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POTENTIAL IMMUNOMODULATION ACTION OF PARTIAL ACYLATED INTERLEUKIN-2 IN EXPERIMENTS
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.13, No. 13)Publication Date: 2006-12-30
Authors : E.A. Romanova; A.V. Martyno; N.I. Igumnova; T.A. Sidorenko; V.I. Chernyavsky; M.V. Smelyanskaya; S.D. Peremot;
Page : 49-52
Keywords : blasttransformation; lymphocytes; immunostimulation; interleukin-2;
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Abstract
In the article were presented results about studied of immunopotential activity of new IL-2 ? acylated derivatives. It was show, that preparation much increased spontaneous blasttransformation of lymphocytes in mice as in vitro and in vivo. Added of acIL-2 to lymphhocete's cells culture resulted to more increasing of mitotic activity of lymphocytes than in control with native Roncoleukin.
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