CHANGE OF LEVELS TNF-Α AND STNFR FOR THE PATIENTS WITH A CHRONIC HEART FAILURE ON A BACKGROUND OF THERAPY

The changes of a level TNF-ά and sTNFR in serum of blood for the patients with a chronic heart failure (СН) on a background of therapy are researched. 64 patients with СН II-IV FC are inspected according to NYHA by functional classification. The patients with СН III-IV FC are divided into 2 groups: with a cardiac cachexia (CC) and without СC. Control group - 16 practically healthy people. Before treatment a level of sTNFR1 and sTNFR2 in serum of blood is defined by ELISA method. The observed data allow to utilize the obtained data as a criterion at production of the diagnosis СН and evaluation of efficacy of the treatment. The degree of augmentation of concentration of the investigated factors in serum of blood allows to estimate a degree of manifestation СН, that would entitle the usage of antagonists in the therapy.