The correlation between individual biochemical parameters of functional state of the liver in experimental obstructive jaundice and course administration of L-lysine escinate and glutargine
Journal: Medicni perspektivi (Vol.21, No. 4)Publication Date: 2016-12-22
Authors : Desjateryk V.I.; Mamchur D.V.; Kotov O.V.; Dronov S.M.; Zhyliuk V.I.;
Page : 8-15
Keywords : experimental obstructive jaundice; superoxide dismutase; malonic dialdehyde; oxidative modification of proteins; bilirubin; hepatic transaminases; correlation;
Abstract
The aim of this study was to determine the correlations between markers of oxidant-antioxidant stress in the blood of experimental animals, as well as the content of bilirubin and activity of enzymes in experimental obstructive jaundice. Studies were conducted on 84 adult male Wistar rats (180-230 g). Animals were divided into 4 groups: intact (n = 12), control (n = 24), L-lysine escinate (0,5 mg/kg, n = 24) and glutargin (40 mg/kg, n = 24). The isolation and ligation of the common bile duct below confluence was carried out under general anesthesia. The test preparations were administered 1 time per day, intraperitoneally. Evaluation of the treatment efficacy was carried out on 4th and 10th day of the study. The content of malonic dialdehyde (MDA), aldehyde- (APH) and ketone-phenylhydrazones (CPH), bilirubin and the activity of superoxide dismutase (SOD), catalase, aspartate aminotransferase (ALT) and alanine aminotransferase (AST) in the blood were determined using conventional techniques. The correlation links between common markers (bilirubin, AST, ALT) and indicators characterizing oxidant-antioxidant stress (MDA, APH, CPH, SOD, catalase) were determined in the study. High rate of correlation between them was established. The results allow to evaluate indirectly the intensity of oxidative metabolism processes in the liver, which can be used in clinical practice to assess the severity degree of the patients with progressive obstructive jaundice.
Other Latest Articles
- GEORGIY VICTOROVYCH DZYAK ? GREATNESS OF PERSONALITY AND LIFE
- The Manisa Palace Hammam /// Manisa Saray Hamamı
- Ottoman Period Structures in Umurbey Town Of Lapseki /// LAPSEKİ’NİN UMURBEY BELDESİNDE OSMANLI DEVRİ YAPILARI
- Ayancık Arkhangelos Church /// AYANCIK ARKHANGELOS KİLİSESİ
- Sociology of Art Attempts /// SANAT SOSYOLOJİSİ GİRİŞİMLERİ
Last modified: 2017-01-16 20:50:45