SYNERGISTIC ROLE OF FOOD BIO - MOLECULES IN CELLULAR PROLIFERATION AND CYTOTOXIC ACTIVITY

Nutrigenomics is the study of molecular relationships between nutritional stimuli andthe response of the genes. The metabolic signals that the nucleus receives from internal factors (hormones) and external factors (nutrients) are responsible for maintaining the functional integrity of genes, wit h the latter being more influential of environmental stimuli. In response to many types of environmental stimuli including nutrition, the human genomes evolve. Herbs promote proliferation of tissue progenitor cells. Identification of multi - potential progen itor population is important for understanding the developmental process and tissue homeostasis. Progenitor population are ideal targets for analysing the cellular metabolism, gene therapy, cell transplantation, and tissue engineering. Chicken has been use d as a favourite model in embryology and developmental biology and it serves as a good model for nutrigenomic studies, in other mammalian system including humans due to its closeness to the mammalian genome. In the present study progenitor cell population from the chicken tissues such as muscle, bone marrow, heart and liver were isolated and cultured for analysing the interactions with food biomolecules. Preliminary studies showed that 11.11±0.05 million cells (heart), 9.63±0.05 million cells (liver), 1.66± 0.05 million cells (muscles). The progenitor population were subjected for different concentrations of isolated food biomolecules derived bio - peptide combinations.