Polymorphism of genes for alcoholdehydrogenase, cysticfibrosis, pancreatic secretory trypsin inhibitor, a cationic trypsinogen in patients with chronic pancreatitis

The study involved 63 patients with a verified diagnosis of chronic pancreatitis. In the 1st group included 31 patients with a complicated clinical forms of chronic pancreatitis, in 2st group included 32 patients with uncomplicated forms. The study analyzed the polymorphisms of genes PRSS1 (mutation R122H) - gene for cationic trypsingene, CFTR1 (mutation del508) - the gene for cystic fibrosis-1, CFTR2 (mutation Gly542Ter) - the gene for cystic fibrosis-2, SPINK1 (mutation N34S) - gene for pancreatic secretory trypsin inhibitor, gene ADH (ADH1B * 2). The study found a statistically significant correlation between ADH gene polymorphism and the risk of complicated forms of chronic pancreatitis.