Revascularization of Permanent Premolars; Report of Three Cases with Clinical and Radiographic Outcomes

Objective: Revascularization is a treatment in immature necrotic teeth which allows the continuation of root development. The aim of the present report was to introduce the successful regenerative endodontic treatment of three immature premolar teeth. Study Design: The root canals were irrigated with 2.5% sodium hypochlorite with minimal instrumentation, followed by tri-antibiotic paste dressing (metronidazole, ciprofloxacin, amoxicillin). Instead of minocycline that is principally recommended for regenerative procedures, amoxicillin was used in order to avoid the discoloration of the crown. At a subsequent visit, the antibiotic paste was removed. A blood clot aroused in the canal by irritating periapical tissues and the root canals were sealed with MTA or BioAggregate, glass ionomer cement, and composite resin. Conclusion: After 18, 24, and 30 months of radiographic and clinical followups respectively, the teeth were asymptomatic without discoloration, and the root developments were continued. It can be suggested that amoxicillin can be used successfully instead of minocycline in order to eliminate discoloration for regenerative endodontic treatment procedures.