ELECTROCHEMICAL BEHAVIOUR OF TROMANTADINE HYDROCHLORIDE AT DIFFERENT ELECTRODES AND ITS ANALYTICAL APPLICATIONS

A simple, sensitive, rapid and precise method was developed using voltammetric techniques namely; cyclic voltammetry, differential pulse and square wave voltammetry for the determination of Tromantadine Hydrochloride (TH) at three different working electrodes namely; glassy carbon (GCE), carbon paste (CPE) and pencil graphite (PGE) electrodes. Firstly, we began with cyclic voltammetric analyses to optimize the voltammetric conditions. TH cyclic voltammogram revealed a well-defined irreversible anodic peak at about 0.751 V, 0.692 V and 0.784 V at GCE, CPE and PGE, respectively. The oxidation process was shown to be irreversible diffusion-controlled for GCE and PGE and adsorptive stripping for CPE. Based on this study, a sensitive quantitative method is recommended for the determination of TH as a pure raw material and in its pharmaceutical formula. The proposed method is validated and compared with the results obtained from the reported valid method. It revealed good accuracy and reproducible results. Keywords: Tromantadine Hydrochloride; Voltammetry; Electrochemical Determination; Oxidation; Adsorptive Stripping; Glassy Carbon Electrode; Carbon Paste Electrode; Pencil Graphite Electrode.