NOVEL 6 - IODO - 3H - QUINAZOLIN - 4 - ONE DERIVATIVES: CLASS OF PHARMACEUTICAL ACTIVE SCAFFOLD

Quinazolinone, a hetetocyclic compound, has been extensively studied and used in certain specific biological activities. 3H - quinazolin - 4 one and its derivative constitute an important class of fused heterocycles that are found in more than 200 naturally occurring alkaloids. With passage of time newer and more complex variants of quinazolinone structure are being discovered. Novel scaffold of 3H - quinazolin - 4 one was synthesized by the base catalysed cyclisation of cromenamodo with 3:5 - dinitrophenyl hydrazine hydrate. The overall reaction was conventional multistep process. The structure of synthesized co mpounds was confirmed on the basis of elemental analysis, IR and NMR spectra results. The pharmacological studies of title compounds were screened for s.aureus, b.subtilis gram positive bacteria, E. coli, P.aeruginosa gram negative bacteria and A.niger, C. albican plant pathogens for antifungal activity in vitro by disc diffusion method. The strength of synthesized compounds was compared with standard drug.