Antidiabetic effect of 2 nitro benzimidazole in alloxan induced diabetic rats

Background: The objective of study was to evaluate the antidiabetic activity of 2 nitro benzimidazole in alloxan induced diabetes in rats. Methods: Alloxan induced diabetic rats (n = 6) were administered 2 nitro benzimidazole (15 mg/kg, p.o.) or vehicle (gum acacia solution) or standard drug glibenclamide (10 mg/kg) for 7days. Blood samples were collected from the tail vein and blood glucose levels were estimated on days 1, and 7 at 0, 2, 4 and 6 hr after administration of drug by a glucometer. Results: The test drug 2 nitro benzimidazole induced significant reduction (P < 0.001) of blood glucose levels in alloxan induced diabetic rats at 2nd and 4 hr comparable with glibenclamide on the 1 and 7th days. The results were analyzed for statistical significance using one-way ANOVA, followed by Dunnet's test. P < 0.05 was considered significant. Conclusion: 2 nitro benzimidazole exhibited significant antihyperglycemic activity in alloxan-induced diabetic rats comparable to that of the standard drug glibenclamide. [Int J Basic Clin Pharmacol 2013; 2(6.000): 814-818]