DEVELOPMENT AND OPTIMIZATION OF POLYMERIC GASTRORETENTIVE MICROSPHERES OF FAMOTIDINE WITH NATURAL BIOENHANCERS

Aim: The aim of present work was to develop microspheres of Famotidine using natural bioenhancers to achieve sustained action for treatment of Peptic ulcer. Method: Ionotropic gelation method was used for the development of microspheres. During preliminary trials, optimum concentration of all the ingredients were selected through entrapment efficiency, dissolution studies method. An optimized formulation was prepared and evaluated for mean particle size, percentage buoyancy, dissolution studies, micromeritic studies. Microscopic characteristics of the optimized formulation were studied using Scanning electron microscopy. Stability studies and releae kinetics were studied for the optimized formulation. Result: After preliminary trials, F5, F9, F11 and F13 were selected on the basis of entrapment efficiency and dissolution studies and their concentrations were utilised for preparing optimized formulation. Optimized Formulation of famotidine containing bio enhancers showed excellent floatability, good buoyancy, better micromeritics properties and increment in drug release. It was observed that release follows first order kinetics and good stability was observed for 2 months during stability studies. Conclusion: Current results indicate a promising approach of Famotidine microspheres, as an alternative for treating Peptic ulcer. Keywords: Famotidone, Bioenhancers, Dissolution studies, Microspheres, Peptic ulcer