Bone hormonal function in postmenopausal women with type 2 diabetes

The aim of the study is the evaluation of hormonal activity of bone tissue in women, depending on age, duration of menopause, and the presence of diabetes mellitus (T2DM). Materials and methods. A total of 68 women were divided into 2 groups: control ? 29 healthy postmenopausal women (mean age (58,41Ѓ}1,17) years), the second ? 39 postmenopausal women with T2DM (mean age (63,46Ѓ}1,21) years, mean HbA1c 9,07+0,36%, the average duration of diabetes (12,05Ѓ}1,37) years). The content of serum osteocalcin was determined by ELISA. Considered normal values of serum osteocalcin concentration for postmenopausal women were 15?46 ng/ml. Results and discussion. It was shown that the concentration of serum osteocalcin of postmenopausal women with T2DM was significantly lower compared to controls (17,49Ѓ}1,20 ng/ml and 32,66Ѓ}2,79 ng/ ml, P<0,001). The content of osteocalcin in blood with T2DM was significantly lower in women of different ages and in women with different postmenopausal duration compared with the control. There were no statistically significant differences of blood osteocalcin in postmenopausal women with different duration of T2DM. Type of glucose-lowering therapy does not affect on the content of osteocalcin in the blood. Results of the study of hormonal activity of bone tissue have shown that T2DM inhibits the endocrine function of bone tissue and slows the rate of bone synthesis. Conclusions. T2DM reduces the level of endocrine function of bone tissue. This suppressive effect on hormonal activity persists in women of all ages and does not depend on the duration of postmenopause, duration of diabetes and the type of hypoglycemic therapy.