FAMILIAL TESTICULAR FEMINISATION SYNDROME. Brothers grown up as beautifulsisters.XY Females in a family

FAMILIAL TESTICULAR FEMINISATION SYNDROME(BROTHERS GROWN UP ASBEAUTIFUL SISTERS).XY FEMALES IN A FAMILY. ABSTRACT TFS is a rare form of malePseudohermaphroditism with an incidence of 1 in 20,000 to 64,000. Individuals with complete formhave female genitalia and incomplete form have ambiguous genitalia which makes the diagnosiseasy. CASE SUMMARYA 21 year girl attended OPD with complaints of not attained menarche. Onexamination she was phenotypically female with sparse pubic and axillary hair. Her younger sisterwho was 18 years old also had similar complaints. On evaluation both of them had high testosterone,absent uterus with BL gonads. Karyotyping was done, found to be XY. They were proceeded withGonadectomy with HRT. The HPE showed presence of testicular tissue. Familial TesticularFeminisation syndrome is a rare entity and only few cases are reported till now