Investigation of molecular biology of leukaemia inhibitory factor (LIF): A Bioinformatics approach
Journal: International Journal of Biosciences (IJB) (Vol.1, No. 3)Publication Date: 2011-06-10
Authors : Sanuwarul Kabir; Abdullah-Al-Emran; Zinnia Naoshin; Farzana Ahmed;
Page : 20-28
Keywords : Leukemia inhibitory factor; bioinformatics; molecular properties; orthologs; paralogs.;
Abstract
Leukaemia inhibitory factor (LIF) is a glycoprotein with a variety of functions in different organ systems. It has great impact on embryogenic stem cell as it is required to maintain the differentiated state of a cell. In our study we tried to find out various molecular features of LIF in human such as conserved domains, important transcription factors, sequence motifs, protein motifs, conserved miRNA binding site and single nucleotide polymorphisms with the help of bioinformatics tools. We also tried to generate a generalized downstream signaling pathway for LIF. These findings could be used to control the expression of LIF for treatment and better drug designing.
Other Latest Articles
- An overview of lactic acid bacteria
- Studies on the reconstitution properties of stored dried spotted spanish mackerel (Scomberomorus guttatus)
- Heavy metal analysis and effect of the crude extract of the leaves of Brysocarpus coccineus and Ficus exasperata on some pathogenic organisms
- Homology modeling and structure prediction of thioredoxin (TRX) protein in wheat (Triticum aestivum L.)
- Solid state fermentation of Jatropha curcas kernel cake with cocktail of fungi
Last modified: 2017-02-28 01:41:19