HEREDITORY NEPHRITIS - A CASE SERIES

Alport syndrome is a primary basement membrane disorder whose most common and earliest manifestation is gross or microscopic hematuria. Hematuria is usually persistent in males and may be intermittent in females. Bilateral sensorineural hearing loss is a characteristic feature observed frequently, but not universally. Anterior lenticonus is the ocular manifestation seen associated with 15 - 20 percent of patients.2 pairs of siblings with Alport syndrome that presented to our OPD at the same time period are hereby presented. Two of them presented with features of renal failure while two others presented with altered sensorium. All the four cases had sensory neural hearing loss and anterior lenticonus. We present this case series as they all presented as sporadic cases without any significant family history