MULTIPLE MYELOMA AND EXTRAMEDULLARY MANIFESTATIONS - A case Report

Plasma cell myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin and usually presents with the classical CRAB (hyperCalcemia, Renal failure, Anemia, Bone lesions) symptoms. Extramedullary disease in plasma cell disorders can be either solitary plasmacytomas of bone (SBP) or multiple myeloma with extramedullary plasmacytomas (EPMM). We report the case of a 58 year old man who had a lesion in the patella followed by lesions in the pleura and lung, all of which were histopathologically confirmed to be myeloma. He also had the classical CRAB symptoms, though this was one of the latest manifestations. Extramedullary manifestations at diagnosis or during the course of multiple myeloma are rare with a cumulative incidence of 4.6 of multiple myeloma. Special characteristics, prognosis and treatment options are discussed here.