MATERIALS TO TREAT THE SKIN DEFECTS: CHITOSAN DERIVATIVES AND PERSPECTIVES FOR THEIR APPLICATION ( LITERATURE REVIEW)

Nowadays it is impossible to treat the skin defects without certain medicines. These drugs are aimed to normalise the microenvironment, enhance the healing process and prevent further complications. The literature review analyzes the steps how wound therapy develops. It also informs about the widely applied materials in surgery and compares these materials due to their efficiency, side effects and pharmacological and economical features. The part of review is devoted to study chitosan-based materials ? a derivative of chitin that is a biologically active polymer. Some commercial and experimental materials have been synthesized from chitin to be later applied in surgery. The references confirm that chitosan derivatives may be widely applied both to optimize and stimulate the healing process, and to prevent complications (infections, scars and the chronic process).