CHANGES IN METABOLISM IN MEN OF MATURE AGE, WHO SUFFER FROM PSORIASIS

The aim of the investigation was to determine the changes in metabolism: daily changes in prooxidant and antioxidant systems, functioning of cell membranes and the state of endogenous intoxication in patients with psoriasis and healthy men of different age. I examined 28 men aged 45-64 years, who suffer from psoriasis, 40 healthy men aged 45-64 years, 35 healthy men aged 25-44 years. For the first time it was found that the dicrease of diurnal fluctuations in activity of peroxide oxidation of lipids, the growth of its overall activity, inadequate response of antioxidative system occured; violations of the functioning of cell membranes were marked and the growth of endotoxicosis occured in men with increasing age. The system of antioxidant protection almost did not respond on the diurnal activity of lipid peroxidation in men of older age groups, who suffered from psoriasis. I observed the decrease of resistancy of membranes and the increase in manifestations of endotoxicosis. Those were pathogenetic links of the disease. I proved the necessity to take measures aimed at improving metabolism in men of older age groups.