PECULIARITIES OF BLOOD CYTOKINE SPECTRUM IN THE PATIENTS WITH REACTIVE ARTHRITIS DUE TO ETIOLOGY, INFLAMMATION ACTIVITY AND PRESENCE OF HLA-B27 ANTIGENJournal: Journal of Clinical and Experimental Medical Research(JC&EMR) (Vol.1, No. 2)
Publication Date: 2013-07-02
Authors : Khukhlina O. S. Zaliavska O. V.;
Page : 181-184
Keywords : reactive arthritis; chronic pyelonephritis; HLA-B27; cytokines; inflammation;
The aim of our study was to investigate the cytokine profile due to the etiology, inflammation activity, and presence of HLA-B27 antigen in the patients with reactive arthritis. The study showed a direct dependence of IL-4, IL-6 and the TNF-α on the degree of activity of ReA with chronic pyelonephritis. The presence of HLA-B27 antigen in the patients with reactive arthritis and chronic pyelonephritis accompanied by an increasing of proinflammatory cytokines such as IL-1β, IL-6, PNP-α, IL-1R in comparison with the HLA-B27-negative patients. The results of study demonstrated that maximum serum levels of IL-6 and IFN-γ in the patients with reactive arthritis that occurred on the background of acute urogenital infection were significantly higher than in the other etiological cases of reactive arthritis.
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