ENHANCEMENT IN SOLUBILITY OF GLIBENCLAMIDE AND CLOFIBRATE DRUGS USING CARBOHYDRATE BASED NON-IONIC SURFACTANTS BY MICELLIZATION

The solubility enhancement process of hydrophobic drugs plays a key role in the formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. As estimated, among the newly discovered chemical entities nearly 40% drugs are poorly water soluble. To get proper therapeutic level of drug in plasma, a high dose of poorly water soluble drugs is required. The orally administered drugs show its complete pharmacological effect if it is fairly soluble in water in gastric medium and such drugs show good bioavailability. The enhancement of oral bioavailability of such poorly water soluble drugs remains one of the most challenging aspects of drug development. Various methods are used to enhance the solubility of poorly water soluble drugs in aqueous medium. In this present study, surfactant micellization method was used to enhance the solubility of poorly water soluble drugs viz. glibenclamide, clofibrate. A carbohydrate based nonionic surfactants, which was synthesized in lab, were explored to encapsulate these drugs. It was found that the water solubility of these drugs increased up to many folds. Key Words: poor water soluble drugs, bioavailability, carbohydrate non-ionic surfactant, clofibrate, glibenclamide, micellization