Interleukin 23 P 19 Gene Expressions in Patients with Ulcerative Colitis and its Relation to Disease Severity

Background and Study Aims: The pur pose of This study Is to détermine whether mucosal expression of IL 23 p 19 has rôle in the pathogenèses of ulcerative colitis and its relation to dise ase severity. Materials and Methods: This study was carried out on 50 patients with ulcerative colitis and 10 normal individuals as control. They were divided into: Group I: 27 patients with mild to moderate disease. Group II: 23 patients with severe disease. Group III: 10 normal individuals. All patients and control were subjected to histopathological study, IL-23p19 immunohistochemical staining, IL-23R expression by flow cytometry and serum IL-23 by ELISA. Results: There is significant increased in IL-23p19 gene and IL-23R in ulcerative colitis patients compared with control. Significant positive correlations were detected between increased expression of IL-23 p19 gene, IL-23R, high serum IL-23 and severity of the disease. Conclusion: increased expression of IL-23 p19 gene has a role in the pathogenesis of ulcerative colitis and that targeted therapy directed against IL- 23 p19 may be effective in the treatment. Increased expression of IL-23p19 gene and IL-23R with high serum IL-23 correlate positively with disease severity.