Pattern of Circulating Micro Particles in Patients with Inflammatory Bowel Disease: Review

Inflammatory bowel diseases (IBD) are common group of digestive inflammatory disorder, which characterized defective regulation of adaptive immunity. There are evidences regarding intercellular cooperation affected epithelial cells, macrophages and dendritic cells plays a pivotal role in gut homeostasis. Therefore, dysregulation of this cell cooperation may lead to decreased epithelial integrity and worsening of IBD. In this report we accumulate data about causality role of circulating microparticles (MPs) in IBD and perspective of serial measurements of these biomarkers aimed risk stratification among patients with IBD. We concluded that the pattern of circulating MPs associates with disease activity, stage and histological findings of IBD and therefore it reflects risk of disease progression.