A New Biomarker for Intensive Care Unit Patients: suPAR

Objective: The aim of the current study was to demonstrate the relationship between the suPAR, APACHE II, C-reactive protein (CRP), procalcitonin (PCT) values and the mortality rates of patients under follow-up in the intensive care unit who met the SIRS criteria. Materials and Methods: Patients were selected from the intensive care units for this single-center, prospective study. Inpatientswho had at least two SIRS criteria, were ?18 years of age, and spent a duration of ?72 hours in the intensive care unit were included in the study. The lowest/worst APACHE II score in the first 24 hours, as well as the suPAR, CRP, PCT, lactate values on the days 1 and 5were determined. Results: An evaluation of the ROC curves for the APACHE II score and the suPAR, CRP, PCT and lactate values measured for the patients in intensive care during the first 24 hours indicated that the APACHE II score had the highest AUC (AUC: 0.824), while the next highest AUCs were observed with suPAR1 (AUC: 0.673), PCT1 (AUC: 0.628), lactate1 (AUC: 0.528), CRP1 (AUC: 0.526). An evaluation of the ROC curves for the suPAR, CRP, PCT and lactate values measured on day 5 indicated that the PCT5 value had the highest AUC (AUC: 0.769), while the next highest AUC values were observed with lactate 5 (AUC: 0.733), suPAR5 (AUC: 0.687) and CRP5 (AUC: 0.648). Conclusion: These findings suggest that suPAR levels can be used to predict mortality on admission day but not for follow up.