Custom Cocktail for Curing any Cancer: A Strategy for Destroying any Cancer without Harming the Patient

Drugs for curing any cancer must completely destroy a patient's cancer without harming the patient. To avoid harming the patient, precision-targeted drugs are used to inactivate RNA transcripts that are absent from the patient's normal cells, but present in and essential to the viability of the patient's cancer. Such “cancer-essential” transcripts are from embryo-active genes normally deactivated in adults, but reactivated in cancers, or from oncogenic viruses. For complete destruction of the patient's cancer a “custom cocktail” of precisiontargeted drugs will target multiple cancer-essential transcripts found to be present in and essential to that patient's cancer. This paper describes: the basis for selecting targets in a patient's cancer; selecting drugs for precisely inactivating those targets; and, assembly of a custom cocktail of such drugs designed to provide a safe and effective cure for that patient's cancer. Preparation and use of a custom cocktail for a specific patient entails: 1. A biopsy of the patient's cancer is sequenced to identify the canceressential transcripts present in that cancer. 2. With that information, assemble a cocktail of precision-targeted drugs effective against multiple cancer-essential transcripts found to be present in that patient's cancer, and treat the patient with that custom cocktail. Also described is a basis for possibly obtaining prompt and affordable regulatory approvals for such cocktails. I believe this therapeutics strategy solves the central challenge in treating cancers: how to completely destroy any cancer without harming the patient. It also offers a direct and rapid route to a safe, effective, and affordable treatment for any cancer.