Successful Treatment of Septic Shock with the Use of IgM Enriched Immunoglobulin Solution and Antibiotic Policy

In case of severe infections and sepsis the universal scheme of treatment is still under discussion. Those, which have a proven effectiveness, are included into Surviving Sepsis Campaign treatment guidelines. In cases where standard therapy provided according to the guidelines proves unsuccessful, other options, like administration of IgM enriched immunoglobulin infusions may be justified. The IgM represents a different class of antibodies than IgG, and possesses many unique properties like effective endotoxin inactivation, high level of complement system supported direct bacteriolysis, low concentration phagocytosis stimulation and activation pathways for immune system. But the evidence is still insufficient to support a robust conclusion of benefit for such therapy.