Biochemical marker changes benign hypermobility syndrome (BHMS)

Back ground: The joint hyper mobility syndrome is a condition that features joints that easily move beyond the normal range expected for that particular joint. Hyper mobility joints tend to be inherited. Symptoms of the joint hyper mobility syndrome include pain in the knees, fingers, hips, and elbows. Often joint hyper mobility causes no symptoms and requires no treatment. Treatments are customized for each individual based on their particular manifestations. Aim of the study: To assess the biochemical changes that occur in patients with Benign Hypermobility Syndrome in a rheumatic clinic in south part of Chennai. Materials and methods: The study was conducted from January 2016 - May 2016. Totally 50 young adults of age range between 17-34 who attended the rheumatic clinic with polyarthralgia and low back pain along with various other symptoms are included in the study. Detailed clinical history such as type of pain, duration of pain, musculoskeletal pain on various regions after activities of daily living are monitored and presence of BHMS was recorded using Modified Beighton Criteria. Biochemical investigations such as complete blood count thyroid profile, lipid profile, C - reactive protein, rheumatic factor were analyzed. Results: Totally 50 patients were included in the study. Among the 50 patients, 23 were male and 27 were female. The age was around 17-35 yrs. ESR was found to be increased in 42patients. Fasting blood glucose was found to elevated in 12 patients. Hypothyroidism found in 3 patients. C-reactive protein found to be normal. Conclusion: Asymptomatic biochemical abnormalities are not uncommon in patients with Benign Hyper mobility. These asymptomatic abnormalities pose a challenge to the general practitioners. Dyslipidemias could occur and decreased HDL cholesterol could partly attributed to decreased physical activity due vague aches and pains. Surprisingly elevated ESR warrants further evaluation to rule out relevant causes. Decreased physical activity may contribute to obesity.